Contact: info@alspinc.com



"Traumatic brain injury causes the release of powerful enzymes, especially cathepsin B and               calpain, which kill neurons, activate inflammation and break down the blood vascular wall.                   These pathologies can cause behavioral and cognitive dysfunction in the patient."

        

ALSP's therapeutic approach is to chemically inhibit the enzymes and thereby prevent             the pathology


 NEURONAL DAMAGE

 CALCIUM ENTERS THE NEURON AND  ACTIVATES CALPAIN PROTEASES.  ACTIVATED CALPAIN CAUSES  THE RELEASE OF LYSOSOMAL  PROTEASES, RESULTING IN CELL  DEATH.


 INFLAMMATORY DAMAGE
 THE ACTIVATION OF GLIA CELLS  INCREASES THE SECRETION OF  CATHEPSIN B AND PRO-  INFLAMMATORY CYTOKINES  INTO  THE EXTRACELLULAR SPACE,  RESULTING IN INFLAMMATORY PAIN  AND CELL DEATH.

 VASCULAR DAMAGE
 EXTRACELLULAR CATHEPSIN B  DEGRADES THE EXTRACELLULAR  MATRIX, CAUSING ANEURYSM, BRAIN  EDEMA, HEMORRHAGE AND A  BREAKDOWN OF THE BLOOD BRAIN  BARRIER.